Publications

  • Elizabeth L. Wagner and Jung-Bum Shin. Mechanisms of Hair Cell Damage and Repair (2019). Trends in Neurosciences. 2019 Apr 13.
  • Ting-Ting Du, Dewey JB, Wagner EL, Cui R, Heo J, Park JJ, Francis SP, Perez-Reyes E, Guillot SJ, Sherman NE, Xu W, Oghalai JS, Kachar B, Jung-Bum Shin.  LMO7 deficiency reveals the significance of the cuticular plate for hearing function (2019). Nature Communications. 10(1):1117.
  • Doug Ruhl, Du TT, Wagner EL, Choi JH, Li S, Reed R, Kim K, Freeman M, Hashisaki G, Lukens JR, Shin JB.  Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity (2019).  Journal of Neuroscience. 39(15):2951-2964.
  • Brian Nicholas BD, Francis S, Wagner EL, Zhang S, Jung-Bum Shin. Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity (2017). Front Cell Neurosci. 11:303
  • Shimon Francis, Jocelyn F. Krey, Evan S Krystofiak, Cui R, Sonali Nanda, Wenhao Xu, Bechara Kachar, Peter G. Barr-Gillespie, Jung-Bum Shin. (2015) A Short Splice Form of Xin-Actin Binding Repeat Containing 2 (XIRP2) Lacking the Xin Repeats Is Required for Maintenance of Stereocilia Morphology and Hearing Function. Journal of Neuroscience 35(5):1999-2014.
  • Zoe F. Mann, Benjamin R. Thiede, Weise Chang, Jung-Bum Shin, Helen M. May-Simera, Michael Lovett, Jeffrey T. Corwin, Matthew W. Kelley. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear (2014). Nature Communications. 2014 20;5:3839
  • Matthew R. Avenarius, Katherine W. Saylor, Megan R. Lundeberg, Phillip A. Wilmarth, Jung-Bum Shin, Kateri J. Spinelli, James M. Pagana, Leonardo Andrade, Bechara Kachar, Dong-Seok Choi, Larry L. David, Peter G. Barr-Gillespie. Correlation of actin crosslinker and capper expression levels with stereocilia growth phases (2014). Mol Cell Proteomics. 13(2):606-20.
  • Jocelyn F. Krey, Phillip A. Wilmarth, Jung-Bum Shin, John Klimek, Nicholas E. Sherman, Erin D. Jeffery, Dong-Seok Choi, Larry L. David, Peter G. Barr-Gillespie. Accurate label-free protein quantitation with high- and low-resolution mass spectrometers (2014). J Proteome Res. ;13(2):1034-44.
  • Shimon P. Francis, Josh Katz, Kathryn D. Fanning, Kimberly A. Harris, Brian D. Nicholas, Michael M. Lacy, James Pagana, Paul F. Agris and Jung-Bum Shin (2013) A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity, Journal of Neuroscience. 13;33(7):3079-93
  • Jung-Bum Shin, Jocelyn F. Krey, Ahmed Hassan, Zoltan Metlagel, Andrew N Tauscher, James M Pagana, Nicholas E. Sherman, Erin D. Jeffery, Kateri J. Spinelli, Hongyu Zhao, Phillip Wilmarth, Dongseok Choi, Larry L. David, Manfred Auer and Peter G. Barr-Gillespie (2013) Molecular architecture of the chick vestibular hair bundle. Nature Neuroscience. 16(3):365-74
  • Hongyu Zhao, Diane E. Williams, Jung-Bum Shin, Britta Brügger, Peter G. Gillespie (2012) Large membrane domains in hair bundles specify spatially constricted radixin activation. Journal of Neuroscience. 32(13):4600-9.
  • Kateri J. Spinelli, John E. Klimek, Phil A..Wilmarth, Jung-Bum Shin, Dong-Seuk Choi, Larry L. David, Peter G. Gillespie (2012). Distinct energy metabolism of auditory and vestibular sensory epithelia revealed by quantitative mass spectrometry using MS2 intensity. Proc Natl Acad Sci U S A. 109(5): E268-77.
  • Jung-Bum Shin, Chantal M. Longo-Guess, Leona H. Gagnon, Katherine W. Saylor, Rachel A. Dumont, Kateri J. Spinelli, James M. Pagana, Phillip A. Wilmarth, Larry L. David, Peter G. Gillespie, and Kenneth R. Johnson (2010). The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. Journal of Neuroscience 30 (29): 9683-9694
  • Jung-Bum Shin, James Pagana, Peter G. Gillespie. Twist-off purification of hair bundles. Methods Mol Biol. 2009; 493: 241-56.
  • Jung-Bum Shin, Femke Streijger, Andy Beynon, Theo Peters, Laura Gadzala, Debra McMillen, Cory Bystrom, Catharina E. Van der Zee, Theo Wallimann, Peter G. Gillespie. Hair bundles are specialized for ATP delivery via creatine kinase. Neuron. 2007; 53(3):371-86
  • Leona H. Gagnon, Chantal M. Longo-Guess, Mark Berryman, Jung-Bum Shin, Katherine W. Saylor, Heping Yu, Peter G. Gillespie, and Kenneth R. Johnson. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. Journal of Neuroscience. 2006; 26(40):10188-98.
  • Mathias Senften, Martin Schwander, Piotr Kazmierczak, Concepcion Lillo, Jung-Bum Shin, Tama Hasson, Gwenaëlle S. G. Géléoc, Peter G. Gillespie, David Williams, Jeffrey R. Holt, and Ulrich Müller. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. Journal of Neuroscience. 2006; 26(7):2060-71.
  • Jung-Bum Shin, Dany Adams, Martin Paukert, Maria Siba, Samuel Sidi, Michael Levin, Peter G. Gillespie, and Stefan Gründer. Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner ear hair cells. Proc Natl Acad Sci U S A. 2005; 102 (35):12572-7.
  • Sabrina L. McIlwrath, Jing Hu, Gireesh Anirudhan, Jung-Bum Shin, Gary R. Lewin. The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability. Neuroscience. 2005;131(2):499-511.
  • Jung-Bum Shin, Carlos Martinez-Salgado, Paul A. Heppenstall and Gary R. Lewin. A T-type calcium channel required for normal function of a mammalian mechanoreceptor. Nature Neuroscience. 2003 Jul; 6(7):724-30.
  • Cheryl Stucky*, Jung-Bum Shin* and Gary R. Lewin. Neurotrophin-4. A survival factor for adult sensory neurons. Curr Biol. 2002 Aug 20;12(16):1401
*both authors contributed equally to the work